![]() Multistage aqueous two phase extraction was carried out further to increase the purity of anthocyanins. Similarly, aqueous two phase extraction was carried out for the purification of anthocyanins and process parameters were standardized. Structural stability of purified anthocyanins was confirmed using HPLC-MS/MS. Adsorption was explained best by using Langmuir isotherm. Adsorption isotherm and kinetic studies were carried out to understand the mechanism of adsorption of anthocyanins. Dynamic adsorption and desorption process parameters were standardized. Adsorption of anthocyanins was carried out for the highest recovery and stability compared to the conventional purification methods. ![]() Major emphasis was given to develop a systematic approach for the extraction and purification of anthocyanins from natural sources. Experiments were carried out to standardize the process parameters for separation and purification of target biomolecules from natural sources that are often complex mixture. The present study mainly covers the purification of selected biomolecules employing unit operations adsorption and aqueous two phase extraction. ![]() In two of the applications, the distillation columns were designed via simulations only, and in the third application, a distillation column was designed via pilot plant testing in addition to simulation.Adsorption and liquid-liquid extraction for the downstream processing of anthocyanins. In each case, the extraction column was sized via pilot plant testing. This article presents three case studies involving the design of complete LLE systems with downstream distillation. However, in some cases, phenomena such as foaming and unknown interactions between various components in the system require pilot plant testing of downstream distillation steps to provide a firm basis for the commercial process design. Often, the distillation columns can be designed by first simulating the process and then designing the distillation column internals using known design criteria, hydraulic rating software, and process engineering experience. If the solvent has some solubility in the feed - as is often the case for systems that include an aqueous feed and an organic solvent - then a distillation column will be required to recover and recycle the solvent from the aqueous phase (raffinate).Īs discussed in previous articles (1–2), design of the extraction column almost always requires pilot plant testing to provide data for accurate scale-up and design of the commercial column. Typically, the solvent used for the extraction step must be distilled from the extracted solute and then recycled back to the extraction column. Thus, optimizing the process requires the engineer to focus on the overall integration of the extraction and distillation columns. In most chemical separation applications involving liquid-liquid extraction (LLE), the process will require one or more distillation columns downstream of the extraction column. This article describes the process design of such systems. Liquid-liquid extraction processes often require one or more downstream distillation columns.
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